Braveheart, a Long Noncoding RNA Required for Cardiovascular Lineage Commitment
نویسندگان
چکیده
منابع مشابه
Braveheart, a Long Noncoding RNA Required for Cardiovascular Lineage Commitment
Long noncoding RNAs (lncRNAs) are often expressed in a development-specific manner, yet little is known about their roles in lineage commitment. Here, we identified Braveheart (Bvht), a heart-associated lncRNA in mouse. Using multiple embryonic stem cell (ESC) differentiation strategies, we show that Bvht is required for progression of nascent mesoderm toward a cardiac fate. We find that Bvht i...
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ژورنال
عنوان ژورنال: Cell
سال: 2013
ISSN: 0092-8674
DOI: 10.1016/j.cell.2013.01.003